Cheng Zhang

  • Associate professor

  • Peking University


Basic Information

Dr. Zhang Cheng is an associate professor in Peking University. He obtained his B.Sc. from Shannxi Normal University in 2003 and Ph.D in 2010 in Peking university. In 2010 and 2014, he worked at Purdue university (Chengde Mao’s group) and Arizona state university respectively as a visiting researcher. In recent years, he focused on the frontier area of DNA assembly, molecular circuit based computing and programming, DNA origami assisted nanopore, nano information processing, nanoparticle based molecular design and engineering, and nano information processing.

The goal of his research is utilizing molecular programming and assembling to systematically manipulate the matter at the molecular scale, for applications in nano-engineering and sensing, molecular computing, nanopore sensing, nanotechnology and biomedicine. For instance, design and establish molecular logic circuits, chemical reaction networks for computation and DNA origami based nano-devices; design DNA origami based nanopore detection system. He has served in various international conferences including DNA16, DNA23, BIC-ta (2008-2014). Moreover, He was awarded Natural Science Award of the Ministry of Education in China in 2012.


  • Cheng Zhang*, Zhiyu Wang, Yan Liu, Jing Yang, Yifan Li, Linqiang Pan, Yonggang Ke, Hao Yan, Nicking-Assisted Reactant Recycle to Implement Entropy-Driven DNA Circuit, J. Am. Chem. Soc, 2019.
  • Linqiang Pan, Yingxin Hu, Taoli Ding, Zhiyu Wang, Chun Xie, Zhekun Chen, Jing Yang, Zhang Cheng*. Chemical Communications, 2019. (SCI, IF: 6.3)
  • Xuedong Zheng, Jing Yang, Changjun Zhou, Zhang Cheng*, Qiang Zhang, Xiaopeng Wei, Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis, Nucleic Acids Research, 2019. (SCI, IF: 11.2)
  • Yang Jing, Wu, Ranfeng, Wang Zhiyu, Pan Linqiang, Zhang Qiang, Lu Zuhong, Zhang Cheng*, Entropy-Driven DNA Logic Circuits Regulated by DNAzyme, Nucleic Acids Research, 2018. (SCI, IF: 11.2)
  • Linqiang Pan, Zhiyu Wang, Fanyi Li, Jing Yang, Qiang Zhang, Cheng Zhang*. Nicking enzyme-controlled toehold regulation for DNA logic circuits, Nanoscale, 2017. (SCI, IF: 7.23)
  • Cheng Zhang*, Ranfeng Wu, Yifan Li, Qiang Zhang, Jing Yang, Programmable Regulation of DNA Conjugation to Gold Nanoparticles via Strand Displacement, Langmuir, 2017. (SCI, IF: 3.8)
  • Jing Yang, Shuoxing Jiang, Xiangrong Liu, Linqiang Pan, Cheng Zhang*, Aptamer-Binding Directed DNA Origami Pattern for Logic Gates, ACS Appl. Mater. Interfaces, 2016. (SCI, IF: 8.1)
  • Cheng Zhang*, Jing Yang, Shuoxing Jiang, Yan Liu and Hao Yan, DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly. Nano Letters, 2016. (SCI, IF: 13.59)
  • Jing Yang, Zhichao Song, Shi Liu, Qiang Zhang, Cheng Zhang*, Dynamically arranging gold nanoparticles on DNA origami for molecular logic gates, ACS Appl. Mater. Interfaces, 2016, 22451. (SCI, IF: 8.1)
  • Cheng Zhang*, Linjing Shen, Chao Liang, Yafei Dong, Jing Yang, Jin Xu, DNA sequential logic gate using two-ring DNA, ACS Appl. Mater. Interfaces, 2016, 8, 9370-9376. (SCI, IF: 8.1)
  • Nosheng Song, Cheng Zhang, Linqiang Pan, Tissue-like P Systems with Evolutional Symport/antiport Rules, Information Sciences, 2016. (SCI, IF: 3.36)
  • Yafei Dong, Chen dong, Fei Wan, Jing Yang and Cheng Zhang*, Development of DNA computing and information processing based on DNA-strand displacement, Science China (Chemistry), 2015, (IF: 4.132)
  • Jing Yang, Chen Dong, Yafei Dong, Linqiang Pan, and Cheng Zhang*. Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs. ACS Appl. Mater. Interfaces, 2014, 6 (16), 14486–14492. (SCI, IF: 8.1)
  • Cheng Zhang*, Jingjing Ma, Jing Yang, Yafei Dong, Jin Xu, Selective Control of Gold Nanoparticles based on Circular DNA Strand Displacement, Journal of Colloid and Interface Science, 2014, (SCI, IF: 4.2)
  • Jing Yang, Jingjing Ma, Shi Liu, Zhang Cheng*, A molecular cryptography model based on structures of DNA self-assembly, Chinese Science Bulletin, 2014. (IF: 4.1)
  • Cheng Zhang*, Liuqing Wu, Jing Yang, Shi Liu and Jin Xu, A Molecular Logical Switch beacon controlled by thiolated DNA signals, 2013, Chemical Communications, 2013, 49, 11308-11310. (SCI, IF: 6.3)
  • Cheng Zhang*, Jingjing Ma, Jing Yang, Shi Liu, and Jin Xu, Binding Assistance Triggering Attachments of Hairpin DNA onto Gold Nanoparticles. Analytical Chemistry, 2013, 85 (24), 11973–11978. (SCI, IF: 6.1)
  • Cheng Zhang*, Jingjing Ma, Jing Yang, Nanoparticle aggregation logic computing controlled by DNA branch migration. Applied Physics Letters, 103, 093106, 2013. (SCI, IF: 3.5)
  • Jing Yang, Lingjing Shen, Jingjing Ma, H. Inaki Schlaberg, Shi Liu, Jin Xu, and Cheng Zhang*. Fluorescent Nanoparticle Beacon for Logic Gate Operation Regulated by Strand Displacement. ACS Appl. Mater. Interfaces, 2013, 5, 5392. (SCI, IF: 8.1)
  • Jing Yang, Cheng Zhang, Shi Liu. A Molecular Computing Model for 0-1 Programming Problem Using DNA Nanoparticles. Journal of Computational and Theoretical Nanoscience. doi:10.1166/jctn.2013.3218. (IF: 0.673)
  • Zhang Cheng, Ma Lina, Dong Yafei, Yang Jing and Xu Jin. Molecular logic computing model based on DNA self-assembly strand branch migration. Chinese Science Bulletin, 2012, 57. 58(1):38. (IF: 4.1)
  • Zhang Cheng, Yang Jing, Xu Jin. DNA/AuNP Fluorescent Detecting Nano-Device. Advanced Materials Research 535-537 (2012) pp 455-458.
  • Zhang Cheng, Yang Jing, Xu Jin. Molecular logic computing model based on self-assembly of DNA nanoparticles. Chinese Science Bulletin, 2011, 56 No.33: 3566. (IF: 4.1)
  • Zhang Cheng, Yang Jing, Xu Jin. The Circular DNA Logic Gates with Branch Migration. Langmuir,2010, 26(3): 1416. (SCI, IF: 3.8)
  • Zhang Cheng, Yang Jing, Xu Jin. A “nano-dial” molecular computing model based on circular DNA. Current Nanoscience,2010, 6(3): (IF: 2.437)
  • Zhang Cheng, Yang Jing, Xu Jin. A DNA length reducing computing model for maximum independent set problem. Chinese Science Bulletin, 2010, 55(9): 890. (IF: 1.78)
  • Yang Jing, Zhang Cheng, Xu Jin. A novel computing model of the maximum clique problem based on circular DNA. Science China Information Sciences, 2010, 53(7):1409. (共同第一作者, IF: 1.63)
  • Zhang Cheng, Yang Jing, Xu Jin. Circular DNA Logic Gates with Branch Migration. The 16th International Conference on DNA Computing and Molecular Programming (DNA 16), Hong Kong, 2010, 223-224.
  • Zhang Cheng, Yang Jing. Multiple-input logic beacon controlled by cooperatively binding-induced DNA strand displacement. The 20th International Conference on DNA Computing and Molecular Programming (DNA 20), USA,
  • Zhang Cheng, Yang Jing, Xu Jin. A molecular computing model for 3-coloring problem based on circular DNA branch migration. Proceedings: 2009 Fourth International Conference on Bio-Inspired Computing: Theories and Applications, 2009, pp:302-306.
  • Yang Jing, Zhang Cheng, Xu Jin. Molecular computations of the maximal clique problem using DNA self-assembly. Proceedings: 2009 Fourth International Conference on Bio-Inspired Computing: Theories and Applications. 2009, pp:230-234.
  • 张成,杨静等。自组装DNA链置换分子逻辑计算模型。科学通报,2012,57: 2909-2915.
  • 张成,杨静等. 自组装DNA/纳米颗粒分子逻辑计算模型,科学通报,2011,56(27): 2276-2282.
  • 杨静,张成等. 基于环形DNA分子的一种求解最大集团的计算模型. 中国科学F,2010,40(8):1078-1085. (共同第一作者)
  • 张成,杨静等. DNA缩短法计算模型求解最大独立集问题. 科学通报,2009,54(24): 3913-3919.
  • 张成,杨静,王淑栋. DNA计算中荧光技术的应用及其发展. 计算机学报,2009, 32(12): 2300-2310.
  • 杨静,张成. DNA自组装技术的研究进展及难点. 计算机学报, 2008,31(12): 2138-2148.
  • 万菲, 董晨, 杨静, 董亚非,张成*. DNA计算技术的发展与应用. 中科院院刊


  • 基于环形DNA的图着色计算方法及其DNA计算系统;
  • 基于DNA计算实现的图顶点着色方法和DNA计算系统;
  • 一种DNA自组装结构和基于其的对称加密系统
    专利号:ZL 2014 1 0219347.5

Research project

  • 科技部国家重点研发计划重点专项: 基于 DNA 自组装复合纳米孔技术的生物大分子检测 (2019年,400万,主持)
  • 北京市联合研发及大科学计划专项:基于DNA自组装的复合纳米孔器件研究 (2019-2021,400万,主持)
  • 国家自然科学基金面上项目:基于荧光传感的DNA计算系统(2018年,80万,主持)
  • 教育部装备联合基金:分子自组装纳米3D打印技术的研究(2018,80万,主持)
  • 北京市自然科学基金:结合DNA自组装的可变构固态纳米孔(2018-2020,20万,主持)
  • 国家自然科学基金面上项目:模块化自组装DNA计算模型的研究(2017, 20万,主持)
  • 国家自然科学基金重大应急专项:基于DNA计算的人工智能新方法,(2017, 220万,参与)
  • 国防预研项目:基于DNA计算的纳米系统研究(2013, 20万,主持)
  • 国家自然基金重点项目:基于机器学习的蛋白质相互作用与功能预测方法研究(2013, 280万,子课题负责人)
  • 国家自然科学基金面上项目:自组装DNA纳米颗粒计算模型的研究(2012, 80万,主持)
  • 国家自然基金重大仪器专项:自组装DNA纳米芯片分子信号综合检测系统,(2012, 280万,第1参与人)
  • 国家博士后特别资助基金项目:自组装DNA纳米颗粒分子高密存储器件(2011, 10万,主持)
  • 国家自然基金重点项目:基于细胞(膜与核酸)的计算模型和算法研究,(2011, 280万,子课题负责人)
  • 国家博士后基金项目:环形DNA密码技术的研究(2010, 5万,主持)