Research areas in the Cheng Zhang’s Group mainly focus on the complex DNA molecular circuit and computing, DNA assembly assisted single molecular nanopore detection, programmable DNA/nanoparticle assembly, single molecular FRET, super-resolution single molecular analysis, DNA origami nanodevice design and fabrication, and applications development for DNA molecular control and engineering.
Our research is multidisciplinary, involving concepts and expertise from bioengineering, chemistry, material science, physics, and electrical engineering, mathematics, computer science. The synthesis and design of DNA assembled nanostructures and nanodevices is carried out in multiple steps including wet experiments and model simulations, where computer assisted design and analysis are often required. Using these well designed DNA nanostructures and circuits, we further want to explore them to the intracellular environments. The nanodevices of current interest are iterative complex molecular circuit and nanodevice, programmable assembled nanopore analysis, addressable nanoparticles assembly, nanoparticle based intracellular detection and origami based super-resolution image.